People
Maria João Romão
Research Group Coordinator
Research Group
Position
Full Professor (since 2012)
Personal Website
Email
mjr@fct.unl.pt
Phone number
(+351) 212948310 (ext: 10963/2)
ORCID
Ciência Vitae
Recent publications
- Vilela-Alves, G; Manuel, RR; Viegas, A; Carpentier, P; Biaso, F; Guigliarelli, B; Pereira, IAC; Romao, MJ; Mota, C. 2024. Substrate-dependent oxidative inactivation of a W-dependent formate dehydrogenase involving selenocysteine displacement. Chemical Science, 15, DOI: 10.1039/d4sc02394c
- Vilela-Alves, G; Manuel, RR; Oliveira, AR; Pereira, IC; Romao, MJ; Mota, C. 2023. Tracking W-Formate Dehydrogenase Structural Changes During Catalysis and Enzyme Reoxidation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24, DOI: 10.3390/ijms24010476
- Oliveira, AR; Mota, C; Klymanska, K; Biaso, F; Romao, MJ; Guigliarelli, B; Pereira, IC. 2022. Spectroscopic and Structural Characterization of Reduced Desulfovibrio vulgaris Hildenborough W-FdhAB Reveals Stable Metal Coordination during Catalysis. ACS Chemical Biology, 17, DOI: 10.1021/acschembio.2c00336
- Mota, C; Diniz, A; Coelho, C; Santos-Silva, T; Esmaeeli, M; Leimkuhler, S; Cabrita, EJ; Marcelo, F; Romao, MJ. 2021. Interrogating the Inhibition Mechanisms of Human Aldehyde Oxidase by X-ray Crystallography and NMR Spectroscopy: The Raloxifene Case. JOURNAL OF MEDICINAL CHEMISTRY, 64, DOI: 10.1021/acs.jmedchem.1c01125
- Pedro Ferreira; Nuno MFSousa ACerqueira; Pedro Alexandrino Fernandes; Maria João Romão; Maria João Ramos. 2020. Catalytic Mechanism of Human Aldehyde Oxidase. ACS Catalysis, DOI: 10.1021/acscatal.0c02627
- Oliveira, AR; Mota, C; Mourato, C; Domingos, RM; Santos, MFA; Gesto, D; Guigliarelli, B; Santos-Silva, T; Romao, MJ; Pereira, IAC. 2020. Toward the Mechanistic Understanding of Enzymatic CO2 Reduction. ACS Catalysis, 10, DOI: 10.1021/acscatal.0c00086
- Terao, M; Garattini, E; Romao, MJ; Leimkuhler, S. 2020. Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes. JOURNAL OF BIOLOGICAL CHEMISTRY, 295, DOI: 10.1074/jbc.REV119.007741
- Ferreira, P; Cerqueira, NMFSA; Coelho, C; Fernandes, PA; Romao, MJ; Ramos, MJ. 2019. New insights about the monomer and homodimer structures of the human AOX1. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 21, DOI: 10.1039/c9cp01040h
- Cristiano Mota; Teresa Santos-Silva; Mineko Terao; Enrico Garattini; Maria João Romão; Silke Leimkühler. 2019. Aldehyde Oxidases as Enzymes in Phase I Drug Metabolism. Pharmaceutical Biocatalysis, DOI: 10.1201/9780429295034-13
- Cristiano Mota; Mariam Esmaeeli; Catarina Coelho; Teresa Santos‐Silva; Martin Wolff; Alessandro Foti; Silke Leimkühler; Maria João Romão. 2019. Human aldehyde oxidase ( hAOX 1): structure determination of the Moco‐free form of the natural variant G1269R and biophysical studies of single nucleotide polymorphisms. FEBS Open Bio, DOI: 10.1002/2211-5463.12617
- Mota, C; Coelho, C; Leimkuhler, S; Garattini, E; Terao, M; Santos-Silva, T; Romao, MJ. 2018. Critical overview on the structure and metabolism of human aldehyde oxidase and its role in pharmacokinetics. COORDINATION CHEMISTRY REVIEWS, 368, DOI: 10.1016/j.ccr.2018.04.006
- Terao, M; Romao, MJ; Leimkuhler, S; Bolis, M; Fratelli, M; Coelho, C; Santos-Silva, T; Garattini, E. 2016. Structure and function of mammalian aldehyde oxidases. ARCHIVES OF TOXICOLOGY, 90, DOI: 10.1007/s00204-016-1683-1
Main research interests
- Novel methods for protein crystallization
- Metalloenzymes and Enzymatic Mechanisms
- Molybdoenzymes
- Aldehyde Oxidase and Drug Metabolism
- Cellulosomal enzymes