People
Ana Rita Grosso
Research Lab Leader
Research Group
Position
Assistant Professor (since 2022)
CV
Personal Website
Email
ar.grosso@fct.unl.pt
ORCID
Ciência Vitae
Recent publications
- Soares, M; Wemans, IS; Caldas, P; da Rocha, ST; Grosso, AR. 2025. X-linked transcriptome dysregulation across immune cells in systemic lupus erythematosus. Biology of Sex Differences, 16, DOI: 10.1186/s13293-025-00750-3
- Kraft, M; Schoofs, H; Petkova, M; Andrade, J; Grosso, AR; Benedito, R; De Roo, AK; Boon, LM; Vikkula, M; Kapp, FG; Hägerling, R; Potente, M; Mäkinen, T. 2025. Angiopoietin-TIE2 feedforward circuit promotes PIK3CA-driven venous malformations. NATURE CARDIOVASCULAR RESEARCH, DOI: 10.1038/s44161-025-00655-9
- Raposo, AC; Caldas, P; Jeremias, J; Arez, M; Mateus, FC; Barbosa, P; Sousa-Luís, R; Agua, F; Oxley, D; Mupo, A; Eckersley-Maslin, M; Casanova, M; Grosso, AR; da Rocha, ST. 2025. Gene reactivation upon erosion of X chromosome inactivation in female hiPSCs is predictable yet variable and persists through differentiation. Stem Cell Reports, 20, DOI: 10.1016/j.stemcr.2025.102472
- Gonçalves, C; Cabral, IM; de Matos, APA; Grosso, AR; Costa, PM. 2024. Transcriptome profiling of the posterior salivary glands of the cuttlefish <i>Sepia officinalis</i> from the Portuguese West coast. Frontiers in Marine Science, 11, DOI: 10.3389/fmars.2024.1362824
- Cabral, IM; Gonçalves, C; Grosso, AR; Costa, PM. 2024. Bioprospecting and marine 'omics': surfing the deep blue sea for novel bioactive proteins and peptides. Frontiers in Marine Science, 11, DOI: 10.3389/fmars.2024.1362697
- Dantas, T; Abreu, CMC; De-Castro, MJG; Grosso, AR; Valente, JD; Xavier, GD. 2024. 25 de Abril Sempre! Portuguese Science and the 50th anniversary of the Carnation Revolution. Communications Biology, 7, DOI: 10.1038/s42003-024-06229-y
- Carvalho, S; Zea-Redondo, L; Tang, CC; Stachel-Braum, P; Miller, D; Caldas, P; Kukalev, A; Diecke, S; Grosswendt, S; Grosso, AR; Pombo, A. 2024. SRRM2 splicing factor modulates cell fate in early development. Biology Open, 13, DOI: 10.1242/bio.060415
- Caldas, P; Luz, M; Baseggio, S; Andrade, R; Sobral, D; Grosso, AR. 2024. Transcription readthrough is prevalent in healthy human tissues and associated with inherent genomic features. Communications Biology, 7, DOI: 10.1038/s42003-024-05779-5
- Cardoso, BA; Duque, M; Gírio, A; Fragoso, R; Oliveira, ML; Allen, JR; Martins, LR; Correia, NC; Silveira, AB; Veloso, A; Kimura, S; Demoen, L; Matthijssens, F; Jeha, S; Cheng, C; Pui, CH; Grosso, AR; Neto, JL; de Almeida, SF; Van Vlieberghe, P; Mullighan, CG; Yunes, JA; Langenau, DM; Pflumio, F; Barata, JT. 2024. CASZ1 upregulates PI3K-AKT-mTOR signaling and promotes T-cell acute lymphoblastic leukemia. Haematologica, 109, DOI: 10.3324/haematol.2023.282854
- Sobral, Daniel; Martins, Marta; Kaplan, Shannon; Golkaram, Mahdi; Salmans, Michael; Khan, Nafeesa; Vijayaraghavan, Raakhee; et al. 2022. Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development. Communications Biology, 5, DOI: 10.1038/s42003-022-03884-x
- Sobral, D; Francisco, R; Duro, L; Videira, PA; Grosso, AR. 2022. Concerted Regulation of Glycosylation Factors Sustains Tissue Identity and Function. BIOMEDICINES, 10, DOI: 10.3390/biomedicines10081805
- Yu Ting Ong, Jorge Andrade and Max Armbruster, Chenyue Shi, Marco Castro, Ana S. H. Costa, Toshiya Sugino, Guy Eelen, Barbara Zimmermann, Kerstin Wilhelm, Joseph Lim, Shuichi Watanabe, Stefan Guenther, Andre Schneider, Francesca Zanconato, Manuel Kaulich, Duojia Pan and Thomas Braun, Holger Gerhardt, Alejo Efeyan, Peter Carmeliet, Stefano Piccolo, Ana Rita Grosso, Michael Potente. 2022. A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth. Nature Metabolism, 4, DOI: 10.1038/s42255-022-00584-y
- Sabino, JC; de Almeida, MR; Abreu, PL; Ferreira, AM; Caldas, P; Domingues, MM; Santos, NC; Azzalin, CM; Grosso, AR; de Almeida, SF. 2022. Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops. eLife, 11, DOI: 10.7554/eLife.69476
- Andrade J, Shi C, Costa ASH, Choi J, Kim J, Doddaballapur A, Sugino T, Ong YT, Castro M, Zimmermann B, Kaulich M, Guenther S, Wilhelm K, Kubota Y, Braun T, Koh GY, Grosso AR, Frezza C, Potente M.. 2021. Control of endothelial quiescence by FOXO-regulated metabolites.. NATURE CELL BIOLOGY, DOI: 10.1038/s41556-021-00637-6
- Vanda Póvoa; Cátia Rebelo de Almeida; Mariana Maia-Gil; Daniel Sobral; Micaela Domingues; Mayra Martinez-Lopez; Miguel de Almeida Fuzeta; Carlos Silva; Ana Rita Grosso; Rita Fior. 2021. Innate immune evasion revealed in a colorectal zebrafish xenograft model. Nature Communications, DOI: 10.1038/s41467-021-21421-y
- Prudêncio P, Rebelo K, Grosso AR, Martinho RG, Carmo-Fonseca M.. 2019. Analysis of Mammalian Native Elongating Transcript sequencing (mNET-seq) high-throughput data. METHODS, DOI: 10.1016/j.ymeth.2019.09.003
- Prudêncio P, Rebelo K, Grosso AR, Martinho RG, Carmo-Fonseca M.. 2019. Analysis of Mammalian Native Elongating Transcript sequencing (mNET-seq) high-throughput data. METHODS, DOI: 10.1016/j.ymeth.2019.09.003
- Mafalda Ramos de Matos; Ioana Posa; Filipa Sofia Carvalho; Vanessa Alexandra Morais; Ana Rita Grosso; Sérgio Fernandes de Almeida. 2019. A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers. Cancers, DOI: 10.3390/cancers11030391
Main research interests
- Ana Rita's main mission is to decipher pathological conditions using multi-omics approaches and identifying molecular events to be further used as biomarkers and therapeutic targets.
- Highlighting, she has been unveiling (epi)genome/transcriptome alterations that affect tumor evolution and metastasis development.
- Additionally, she has been teaching MSc and BSc courses focused on Multi-Omics and Computational Biology fields in FCT-NOVA.
- RESEARCH AREAS: Computational Biology; Multi-Omics Data Analysis; Gene Expression; Cancer