People
Cristina Amaral
senior researcher
Email
cristinamaralibd@gmail.com
Research Lab
ORCID
Ciência Vitae
Recent publications
- Varela, C; Amaral, C; Gomes, AR; Almeida, CF; Correia-da-Silva, G; Teixeira, N; Tavares-da-Silva, E; Roleira, FMF. 2025. Cutting-edge design approaches for steroidal aromatase inhibitors: new horizons for hormone-dependent cancer. Expert Opinion on Drug Discovery, DOI: 10.1080/17460441.2025.2591082
- Alves, P; Amaral, C; Fonseca, BM; Sousa, LG; Teixeira, N; Correia-da-Silva, G. 2025. Effects of cannabidiol, cannabichromene, cannabidivarin, cannabigerol and cannabinol in endometrial cells: Implications for endocrine and senescence modulation. REPRODUCTIVE TOXICOLOGY, 137, DOI: 10.1016/j.reprotox.2025.109006
- Almeida, CF; Valente, MJ; Teixeira, N; Rocha, S; Ribeiro, AP; Vinggaard, AM; Correia-da-Silva, G; Amaral, C. 2025. Cannabinol improves exemestane efficacy in estrogen receptor-positive breast cancer models: a comparative study with cannabidiol. EUROPEAN JOURNAL OF PHARMACOLOGY, 1000, DOI: 10.1016/j.ejphar.2025.177712
- Almeida, CF; Correia-da-Silva, G; Ribeiro, AP; Amaral, C. 2025. Impact of minor cannabinoids on key pharmacological targets of estrogen receptor-positive breast cancer. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1870, DOI: 10.1016/j.bbalip.2025.159658
- Amaral, C; Almeida, CF; Valente, MJ; Varela, CL; Costa, SC; Roleira, FMF; Tavares-da-Silva, E; Vinggaard, AM; Teixeira, N; Correia-da-Silva, G. 2025. New Promising Steroidal Aromatase Inhibitors with Multi-Target Action on Estrogen and Androgen Receptors for Breast Cancer Treatment. Cancers, 17, DOI: 10.3390/cancers17020165
- Almeida, CF; Palmeira, A; Valente, MJ; Correia-da-Silva, G; Vinggaard, AM; Sousa, ME; Teixeira, N; Amaral, C. 2024. Molecular Targets of Minor Cannabinoids in Breast Cancer: In Silico and In Vitro Studies. PHARMACEUTICALS, 17, DOI: 10.3390/ph17091245
- Almeida, CF; Correia-da-Silva, G; Teixeira, N; Amaral, C. 2024. Influence of tumor microenvironment on the different breast cancer subtypes and applied therapies. BIOCHEMICAL PHARMACOLOGY, 223, DOI: 10.1016/j.bcp.2024.116178
- Almeida, CF; Teixeira, N; Valente, MJ; Vinggaard, AM; Correia-da-Silva, G; Amaral, C. 2023. Cannabidiol as a Promising Adjuvant Therapy for Estrogen Receptor-Positive Breast Tumors: Unveiling Its Benefits with Aromatase Inhibitors. Cancers, 15, DOI: 10.3390/cancers15092517
- Roleira, FMF; Costa, SC; Gomes, AR; Varela, CL; Amaral, C; Augusto, TV; Correia-da-Silva, G; Romeo, I; Costa, G; Alcaro, S; Teixeira, N; Tavares-da-Silva, EJ. 2023. Design, synthesis, biological activity evaluation and structure-activity relationships of new steroidal aromatase inhibitors. The case of C-ring and 7 beta substituted steroids. BIOORGANIC CHEMISTRY, 131, DOI: 10.1016/j.bioorg.2022.106286
- Amaral, C; Correia-da-Silva, G; Almeida, CF; Valente, MJ; Varela, C; Tavares-da-Silva, E; Vinggaard, AM; Teixeira, N; Roleira, FMF. 2023. An Exemestane Derivative, Oxymestane-D1, as a New Multi-Target Steroidal Aromatase Inhibitor for Estrogen Receptor-Positive (ER+) Breast Cancer: Effects on Sensitive and Resistant Cell Lines. MOLECULES, 28, DOI: 10.3390/molecules28020789
- El-Abid, H; Amaral, C; Cunha, SC; Correia-da-Silva, G; Fernandes, J; Moumni, M; Teixeira, N. 2023. Anti-cancer properties of hydroethanolic extracts of Juniperus oxycedrus L. in breast cancer cells. Journal of Herbal Medicine, 37, DOI: 10.1016/j.hermed.2022.100614
- Almeida, CF; Teixeira, N; Correia-Da-silva, G; Amaral, C. 2022. Cannabinoids in breast cancer: Differential susceptibility according to subtype. MOLECULES, DOI: 10.3390/molecules27010156
- Augusto, TV; Amaral, C; Wang, YZ; Chen, SA; Almeida, CF; Teixeira, N; Correia-da-Silva, G. 2021. Effects of PI3K inhibition in AI-resistant breast cancer cell lines: autophagy, apoptosis, and cell cycle progression. BREAST CANCER RESEARCH AND TREATMENT, 190, DOI: 10.1007/s10549-021-06376-4
- Augusto, TV; Amaral, C; Almeida, CF; Teixeira, N; Correia-da-Silva, G. 2021. Differential biological effects of aromatase inhibitors: Apoptosis, autophagy, senescence and modulation of the hormonal status in breast cancer cells. MOLECULAR AND CELLULAR ENDOCRINOLOGY, 537, DOI: 10.1016/j.mce.2021.111426
- Alves, P; Amaral, C; Teixeira, N; Correia-da-Silva, G. 2021. Cannabidiol disrupts apoptosis, autophagy and invasion processes of placental trophoblasts. ARCHIVES OF TOXICOLOGY, DOI: 10.1007/s00204-021-03122-z
- Amaral, C; Trouille, FM; Almeida, CF; Correia-da-Silva, G; Teixeira, N. 2021. Unveiling the mechanism of action behind the anti-cancer properties of cannabinoids in ER+ breast cancer cells: Impact on aromatase and steroid receptors. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 210, DOI: 10.1016/j.jsbmb.2021.105876
- Almeida, CF; Teixeira, N; Oliveira, A; Augusto, TV; Correia-da-Silva, G; Ramos, MJ; Fernandes, PA; Amaral, C. 2021. Discovery of a multi-target compound for estrogen receptor-positive (ER+) breast cancer: Involvement of aromatase and ERs. BIOCHIMIE, 181, DOI: 10.1016/j.biochi.2020.11.023
- Alves P; Amaral C; Teixeira N; Correia-da-Silva G. 2020. Cannabis sativa: Much more beyond Δ9-tetrahydrocannabinol.. PHARMACOLOGICAL RESEARCH, DOI: 10.1016/j.phrs.2020.104822
- Cristina Ferreira Almeida, Ana Oliveira, Maria João Ramos, Pedro A Fernandes, Natércia Teixeira, Cristina Amaral. 2020. Estrogen receptor-positive (ER+) breast cancer treatment: Are multi-target compounds the next promising approach?. BIOCHEMICAL PHARMACOLOGY, DOI: 10.1016/j.bcp.2020.113989
- Almada, M; Amaral, C; Oliveira, A; Fernandes, PA; Ramos, MJ; Fonseca, BM; Correia-da-Silva, G; Teixeira, N. 2020. Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling. REPRODUCTIVE TOXICOLOGY, 93, DOI: 10.1016/j.reprotox.2020.01.003
- Amaral, C; Augusto, TV; Almada, M; Cunha, SC; Correia-da-Silva, G; Teixeira, N. 2020. The potential clinical benefit of targeting androgen receptor (AR) in estrogen-receptor positive breast cancer cells treated with Exemestane. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1866(5), DOI: 10.1016/j.bbadis.2019.165661
- Roleira, FMF; Varela, C; Amaral, C; Costa, SC; Correia-da-Silva, G; Moraca, F; Costa, G; Alcaro, S; Teixeira, NAA; da Silva, EJT. 2019. C-6 alpha- vs C-7 alpha-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure-Activity Relationships. JOURNAL OF MEDICINAL CHEMISTRY, 62, DOI: 10.1021/acs.jmedchem.9b00157
- Amaral C; Augusto TV; Tavares-da-Silva E; Roleira FMF; Correia-da-Silva G; Teixeira N. 2018. Hormone-dependent breast cancer: Targeting autophagy and PI3K overcomes Exemestane-acquired resistance.. The Journal of steroid biochemistry and molecular biology, DOI: 10.1016/j.jsbmb.2018.05.006
- Augusto, TV; Correia-da-Silva, G; Rodrigues, CMP; Teixeira, N; Amaral, C. 2018. Acquired resistance to aromatase inhibitors: where we stand!. ENDOCRINE-RELATED CANCER, 25, DOI: 10.1530/ERC-17-0425
- Cristina Amaral; Maria Regina TToloi; Luis Daniel Vasconcelos; Maria José VFonseca; Georgina Correia-da-Silva; Natércia Teixeira. 2017. The role of soybean extracts and isoflavones in hormone-dependent breast cancer: aromatase activity and biological effects. Food & Function, 8(9), DOI: 10.1039/C7FO00205J
- Sobral, AF; Amaral, C; Correia-da-Silva, G; Teixeira, N. 2016. Unravelling exemestane: From biology to clinical prospects. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 163, DOI: 10.1016/j.jsbmb.2016.03.019
- Amaral, Cristina; Borges, Margarida; Melo, Soraia; da Silva, Elisiario Tavares; Correia-da-Silva, Georgina; Teixeira, Natercia. 2012. Apoptosis and Autophagy in Breast Cancer Cells following Exemestane Treatment. PLoS One, 7(8), DOI: 10.1371/journal.pone.0042398
Main research interests
- Hormone-dependent cancers
- Breast cancer; Aromatase inhibitors; Estrogen receptor modulators; Endocrine/Acquired Resistance;
- Biological effects/Mechanisms of action of steroidal/ non-steroidal/ natural anti-cancer drugs; Multi-target compounds;
- Cannabinoids; Cannabinoid signalling; Cannabis sativa
- Cell death; Cell proliferation; Cell signalling pathways
- Plant Science and Biotechnology