People
Filipa Marcelo
Research Lab Leader
Research Group
Position
CEEC Institutional Assistant Researcher (since 2023)
Personal Website
Email
filipa.marcelo@fct.unl.pt
ORCID
Ciência Vitae
Recent publications
- Andres Manuel Gonzalez-Ramirez and Ana Sofia Grosso and Zhang Yang and Ismael Companon and Helena Coelho and Yoshiki Narimatsu and Henrik Clausen and Filipa Marcelo and Francisco Corzana and Ramon Hurtado-Guerrero. 2022. Structural basis for the synthesis of the core 1 structure by C1GalT1. Nature Communications, 13, DOI: 10.1038/s41467-022-29833-0
- Coelho, Helena; Rivas, Matilde De Las; Grosso, Ana S.; Diniz, Ana; Soares, Cátia O.; Francisco, Rodrigo A.; Dias, Jorge S.; Compañon, Ismael; Sun, Lingbo; Narimatsu, Yoshiki; Vakhrushev, Sergey Y.; Clausen, Henrik; Cabrita, Eurico J.; Jiménez-barbero, Jesús; Corzana, Francisco; Hurtado-guerrero, Ramon; Marcelo, Filipa. 2022. Atomic and Specificity Details of Mucin 1 O-Glycosylation Process by Multiple Polypeptide GalNAc-Transferase Isoforms Unveiled by NMR and Molecular Modeling. JACS Au, DOI: 10.1021/jacsau.1c00529
- Lima, CDL; Coelho, H; Gimeno, A; Trovao, F; Diniz, A; Dias, JS; Jimenez-Barbero, J; Corzana, F; Carvalho, AL; Cabrita, EJ; Marcelo, F. 2021. Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune-Related Lectins. CHEMISTRY-A EUROPEAN JOURNAL, DOI: 10.1002/chem.202100800
- Gabba, A; Bogucka, A; Luz, JG; Diniz, A; Coelho, H; Corzana, F; Canada, FJ; Marcelo, F; Murphy, PV; Birrane, G. 2021. Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen. BIOCHEMISTRY, 60, DOI: 10.1021/acs.biochem.1c00009
- Lenza, MP; Oyenarte, I; Diercks, T; Quintana, JI; Gimeno, A; Coelho, H; Diniz, A; Peccati, F; Delgado, S; Bosch, A; Valle, M; Millet, O; Abrescia, NGA; Palazon, A; Marcelo, F; Jimenez-Oses, G; Jimenez-Barbero, J; Arda, A; Ereno-Orbea, J. 2020. Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, DOI: 10.1002/anie.202011015
- Ana Diniz; Helena Coelho; Jorge SDias; Sandra JVliet; Jesús Jiménez‐Barbero; Francisco Corzana; Eurico JCabrita; Filipa Marcelo. 2019. The Plasticity of the Carbohydrate Recognition Domain Dictates the Exquisite Mechanism of Binding of Human Macrophage Galactose‐Type Lectin. Chemistry – A European Journal, 25(61), DOI: 10.1002/chem.201902780
- Santarsia, S; Grosso, AS; Trovao, F; Jimenez-Barbero, J; Carvalho, AL; Nativi, C; Marcelo, F. 2018. Molecular Recognition of a Thomsen-Friedenreich Antigen Mimetic Targeting Human Galectin-3. ChemMedChem, 13, DOI: 10.1002/cmdc.201800525
- de las Rivas, M; Daniel, EJP; Coelho, H; Lira-Navarrete, E; Raich, L; Companon, I; Diniz, A; Lagartera, L; Jimenez-Barbero, J; Clausen, H; Rovira, C; Marcelo, F; Corzana, F; Gerken, TA; Hurtado-Guerrero, R. 2018. Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4. ACS Central Science, 4, DOI: 10.1021/acscentsci.8b00488
- Matilde de las Rivas, Helena Coelho, Ana Diniz, Erandi Lira-Navarrete, Ismael Compañón, Jesús Jiménez-Barbero, Katrine T. Schjoldager, Eric P. Bennett, Sergey Y. Vakhrushev, Henrik Clausen, Francisco Corzana, Filipa Marcelo, Ramon Hurtado-Guerrero. 2018. Structural analysis of a GalNAc‐T2 mutant reveals an induced‐fit catalytic mechanism for GalNAc‐Ts. Chemistry – A European Journal, 24, DOI: 10.1002/chem.201800701
- Coelho, H; Matsushita, T; Artigas, G; Hinou, H; Canada, FJ; Lo-Man, R; Leclerc, C; Cabrita, EJ; Jimenez-Barbero, J; Nishimura, S; Garcia-Martin, F; Marcelo, F. 2015. The Quest for Anticancer Vaccines: Deciphering the Fine-Epitope Specificity of Cancer-Related Monoclonal Antibodies by Combining Microarray Screening and Saturation Transfer Difference NMR. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137, DOI: 10.1021/jacs.5b06787
Main research interests
- Protein-glycan interactions
- Protein glycosylation
- Molecular Recognition
- NMR