People

Jorge Miguel de Ascenção Oliveira

Research Group Coordinator

Position
Associate Professor with "Agregação" (since 2025)
Research Group
Personal Website
View here
Email
jorgemao@ff.up.pt
Research Lab
ORCID
0000-0002-6040-5355
Ciência Vitae
CA18-D67D-187B

Recent publications

  • Pinho, BR; Martins, V; Chacko, AR; Nogueira, C; Duchen, MR; Oliveira, JMA. 2026. Targeting mitochondrial deubiquitinase USP30 to induce mitophagy in heteroplasmic mitochondrial diseases. Pharmacological Reports, DOI: 10.1007/s43440-026-00829-7
  • Almeida, LM; Lima, LP; Oliveira, NAS; Silva, RFO; Sousa, B; Bessa, J; Pinho, BR; Oliveira, JMA. 2026. The PERK inhibitor GSK2606414 evokes developmental defects in zebrafish consistent with Wolcott-Rallison syndrome phenotypes. Pharmacological Reports, DOI: 10.1007/s43440-026-00837-7
  • Oliveira, NAS; Pinho, BR; Pinto, J; de Pinho, PG; Oliveira, JMA. 2024. Edaravone counteracts redox and metabolic disruptions in an emerging zebrafish model of sporadic ALS. FREE RADICAL BIOLOGY AND MEDICINE, 217, DOI: 10.1016/j.freeradbiomed.2024.03.016
  • Liliana MAlmeida; Brígida RPinho; Michael RDuchen; Jorge MAOliveira. 2022. The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases. BIOLOGICAL REVIEWS, DOI: 10.1111/brv.12860
  • Silva, RFO; Pinho, BR; Monteiro, NM; Santos, MM; Oliveira, JMA. 2022. Automated analysis of activity, sleep, and rhythmic behaviour in various animal species with the Rtivity software. Scientific Reports, 12, DOI: 10.1038/s41598-022-08195-z
  • Pinho, BR; Almeida, LM; Duchen, MR; Oliveira, JMA. 2021. Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation. LIFE SCIENCES, 285, DOI: 10.1016/j.lfs.2021.120009
  • Pinho, BR; Duarte, AI; Canas, PM; Moreira, PI; Murphy, MP; Oliveira, JMA. 2020. The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice. FREE RADICAL BIOLOGY AND MEDICINE, 146, DOI: 10.1016/j.freeradbiomed.2019.11.021
  • Pinho, BR; Reis, SD; Hartley, RC; Murphy, MP; Oliveira, JMA. 2019. Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells. FREE RADICAL BIOLOGY AND MEDICINE, 130, DOI: 10.1016/j.freeradbiomed.2018.10.446
  • Soares, TR; Reis, SD; Pinho, BR; Duchen, MR; Oliveira, JMA. 2019. Targeting the proteostasis network in Huntington's disease. AGEING RESEARCH REVIEWS, 49, DOI: 10.1016/j.arr.2018.11.006
  • Reis, SD; Pinho, BR; Oliveira, JMA. 2017. Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders. MOLECULAR NEUROBIOLOGY, 54, DOI: 10.1007/s12035-016-0120-z

Main research interests

  • Neurobiology
  • Mitochondrial physiology
  • Functional Imaging