Unveiling 3D structure of membrane proteins for medicinal therapies disclosure
Approximately 50% of the world population is estimated to be to be chronically infected with Helicobacter pylori, causing diseases such as gastritis, gastric ulcers and stomach cancer. The eradication of this pathogen involves the use of antibiotics and, thus the resistance of bacteria to such antibiotics is rising rapidly, and, consequently, the need for a specific eradication drug is urgent. Our recent cryo-EM studies describe H. pylori urease in complex with various inhibitors, a potential new therapy against H. pylori.
